To better develop and use mineral resources and take mining activities, this paper, based on mining localities in Da-Xiao Xing'anling area from 2014—2017, uses kernal density estimation and nearest neighbor to study the temporal-spatial distribution and changes of mining intensity in this area, with results indicating that the distribution is not even, concentrating in the southern study area, and transferring to the western Hulun Buir and Chifeng as time goes on. Coal and iron ore mining localities trend to be centralized, with the latter moving to Xunke county of Heihe city, Horqin Right Wing Front Banner of Hinggan League, and Dong Ujimqin Banner of Xilin Gol League. Industrial minerals mining localities are concentrating in the southern study area, further moving southward as economic center shifts to the south. Regional geology and terrain determine the distribution of mining localities; infrastructures, markets and industrial development are the main driving forces; policies are the direct drive to confine and standardize mining activities.